Genomic diversity and antiviral function(s) of a TRIM multigenic family in fish
TRIM proteins constitute a large multigenic family and share a signature at the N terminus, a tripartite motif (TRIM) including a ring zinc finger, a B-Box domain and a coiled-coil (RBCC). The TRIM proteins are involved in many intracellular pathways and have been implicated in different functions such as cell differentiation, apoptosis, and in growth control, but also in cellular defense mechanisms against (TRIM5, TRIM19). Recently a virus-induced TRIM multigenic subfamily (finTRIM) has been identified in teleosts. We hypothesize that this finTRIM subfamily will be important for effective irradication of viral and other infections. This project investigates the genomic diversity, the expression pattern and regulation, the subcellular distribution and the functional properties of finTRIMs. This project is performed in the context of the development of an integrated repertoire of virus-induced modifications of fish transcriptome.
This project is a cooperation between the Wageningen University and The National Institute of Agronomical Research (INRA), Jouy en Josas, France.
Project leader in France is: Dr. P. Boudinot